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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-BAG cochaperone 3 Rabbit Monoclonal Antibody
KD-Validated Anti-BAG cochaperone 3 Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, ICC |
|---|---|
| Primary Accession | O95817 |
| Reactivity | Human, Mouse |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB1520 |
| Calculated MW | Predicted, 6 2 kDa ; Observed, 80 kDa |
| Gene Name | BAG3 |
| Aliases | BAG3; BAG Cochaperone 3; BAG Family Molecular Chaperone Regulator 3; BCL2 Associated Athanogene 3; Bcl-2-Binding Protein Bis; Docking Protein CAIR-1; BAG-3; BIS; Bcl-2-Binding Protein BIS Transcript 2; Bcl-2-Associated Athanogene 3; BCL2-Binding Athanogene 3; CAIR-1; MFM6 |
| Immunogen | A synthesized peptide derived from human Bag3 |
| Gene ID | 9531 |
|---|---|
| Other Names | BAG family molecular chaperone regulator 3, BAG-3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1, BAG3, BIS |
| Name | BAG3 |
|---|---|
| Synonyms | BIS |
| Function | Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8 (PubMed:27884606, PubMed:30559338). Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release (PubMed:27884606, PubMed:30559338). Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD) (PubMed:27474739, PubMed:9873016). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920). |
| Cellular Location | Nucleus. Cytoplasm. Note=Colocalizes with HSF1 to the nucleus upon heat stress (PubMed:26159920) |
Research Areas
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Application Protocols
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$ 149.00
$ 499.00
Cat# AGI2344
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